Enantioselective fluoroamination: 1,4-addition to conjugated dienes using anionic phase-transfer catalysis.
نویسندگان
چکیده
Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 30 شماره
صفحات -
تاریخ انتشار 2013